Protein Details: Calcium-activated chloride channel regulator 2

Protein ID

ICDB_Pro_1678

Protein Name

Calcium-activated chloride channel regulator 2

Gene Name

CLCA2; CACC3

Organism

Homo sapiens (Human)

Length

943 amino acids

AlphaFoldDB

AF-Q9UQC9-F1-model_v4.pdb

Function

Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner; and cell adhesion. Involved in basal cell adhesion and/or stratification of squamous epithelia. May act as a tumor suppressor in breast and colorectal cancer. Plays a key role for cell adhesion in the beginning stages of lung metastasis via the binding to ITGB4.

Sequence

MTQRSIAGPICNLKFVTLLVALSSELPFLGAGVQLQDNGYNGLLIAINPQVPENQNLISNIKEMITEASFYLFNATKRRVFFRNIKILIPATWKANNNSKIKQESYEKANVIVTDWYGAHGDDPYTLQYRGCGKEGKYIHFTPNFLLNDNLTAGYGSRGRVFVHEWAHLRWGVFDEYNNDKPFYINGQNQIKVTRCSSDITGIFVCEKGPCPQENCIISKLFKEGCTFIYNSTQNATASIMFMQSLSSVVEFCNASTHNQEAPNLQNQMCSLRSAWDVITDSADFHHSFPMNGTELPPPPTFSLVQAGDKVVCLVLDVSSKMAEADRLLQLQQAAEFYLMQIVEIHTFVGIASFDSKGEIRAQLHQINSNDDRKLLVSYLPTTVSAKTDISICSGLKKGFEVVEKLNGKAYGSVMILVTSGDDKLLGNCLPTVLSSGSTIHSIALGSSAAPNLEELSRLTGGLKFFVPDISNSNSMIDAFSRISSGTGDIFQQHIQLESTGENVKPHHQLKNTVTVDNTVGNDTMFLVTWQASGPPEIILFDPDGRKYYTNNFITNLTFRTASLWIPGTAKPGHWTYTLNNTHHSLQALKVTVTSRASNSAVPPATVEAFVERDSLHFPHPVMIYANVKQGFYPILNATVTATVEPETGDPVTLRLLDDGAGADVIKNDGIYSRYFFSFAANGRYSLKVHVNHSPSISTPAHSIPGSHAMYVPGYTANGNIQMNAPRKSVGRNEEERKWGFSRVSSGGSFSVLGVPAGPHPDVFPPCKIIDLEAVKVEEELTLSWTAPGEDFDQGQATSYEIRMSKSLQNIQDDFNNAILVNTSKRNPQQAGIREIFTFSPQISTNGPEHQPNGETHESHRIYVAIRAMDRNSLQSAVSNIAQAPLFIPPNSDPVPARDYLILKGVLTAMGLIGIICLIIVVTHHTLSRKKRADKKENGTKLL

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

BINDING 164; /ligand="Zn(2+)"; /ligand_note="catalytic"; BINDING 168; /ligand="Zn(2+)"; /ligand_note="catalytic"; BINDING 175; /ligand="Zn(2+)"; /ligand_note="catalytic";

Disease

Angular Cheilitis and Bestrophinopathy;Autosomal Recessive

Location

Expressed in cornea; skin; vagina; esophagus; and larynx (at protein level). Expressed in trachea and mammary gland. Weakly expressed in testis and kidney. Weakly expressed in testis and kidney. Weakly expressed in testis and kidney. Highly expressed in corneal epithelium; colon and trachea. Moderately expressed in brain; urogenital organs; bladder; uterus and prostate. Highly expressed in tissues containing stratified epithelium including cornea; esophagus; larynx; skin and vagina than those tissues which contain only epithelial monolayers. Expressed in normal breast epithelium but not in breast cancer. Highly expressed during epithelial stratification. Expressed in endothelial cells of lung. Expressed selectively in endothelia of small pulmonary arteries; arterioles; and subpleural and interlobular venules.

DOI ID

10.1152/ajpcell.1999.276.6.c1261; 10.1016/s0014-5793(99)00891-1; 10.1076/ceyr.21.6.918.6983; 10.1038/ng1285; 10.1101/gr.2596504; 10.1089/10445490152122442; 10.1074/jbc.m100478200; 10.1177/002215540405200313; 10.1016/j.acthis.2004.08.003; 10.1007/s00441-005-0059-2; 10.1074/jbc.m605919200; 10.1126/science.1133427

RefSeq

NP_006527.1